{"id":6801,"date":"2022-03-22T11:53:41","date_gmt":"2022-03-22T10:53:41","guid":{"rendered":"https:\/\/miracum.cms.rrze.uni-erlangen.de\/?page_id=6801"},"modified":"2024-05-15T15:04:36","modified_gmt":"2024-05-15T13:04:36","slug":"use-case-1-alerting-care","status":"publish","type":"page","link":"https:\/\/www.miracum.org\/en\/forschung\/archiv\/use-cases\/use-case-1-alerting-care\/","title":{"rendered":"Use Case 1 &#8211; Alerting in Care"},"content":{"rendered":"<h3><span style=\"font-family: helvetica, arial, sans-serif\">IT Support for Patient Recruitment<\/span><\/h3>\n<p><span style=\"font-family: helvetica, arial, sans-serif\"><aside class=\"rrze-elements pull-right\"><p><p><div class=\"rrze-elements notice notice-tipp no-title\"><div><svg height=\"1em\" width=\"1em\" class=\"rrze-elements-icon\" style=\"font-size: 2em;\"  alt=\"Tipp\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 384 512\"><!--! Font Awesome Free 6.6.0 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path fill=\"currentcolor\" d=\"M297.2 248.9C311.6 228.3 320 203.2 320 176c0-70.7-57.3-128-128-128S64 105.3 64 176c0 27.2 8.4 52.3 22.8 72.9c3.7 5.3 8.1 11.3 12.8 17.7c0 0 0 0 0 0c12.9 17.7 28.3 38.9 39.8 59.8c10.4 19 15.7 38.8 18.3 57.5L109 384c-2.2-12-5.9-23.7-11.8-34.5c-9.9-18-22.2-34.9-34.5-51.8c0 0 0 0 0 0s0 0 0 0c-5.2-7.1-10.4-14.2-15.4-21.4C27.6 247.9 16 213.3 16 176C16 78.8 94.8 0 192 0s176 78.8 176 176c0 37.3-11.6 71.9-31.4 100.3c-5 7.2-10.2 14.3-15.4 21.4c0 0 0 0 0 0s0 0 0 0c-12.3 16.8-24.6 33.7-34.5 51.8c-5.9 10.8-9.6 22.5-11.8 34.5l-48.6 0c2.6-18.7 7.9-38.6 18.3-57.5c11.5-20.9 26.9-42.1 39.8-59.8c0 0 0 0 0 0s0 0 0 0s0 0 0 0c4.7-6.4 9-12.4 12.7-17.7zM192 128c-26.5 0-48 21.5-48 48c0 8.8-7.2 16-16 16s-16-7.2-16-16c0-44.2 35.8-80 80-80c8.8 0 16 7.2 16 16s-7.2 16-16 16zm0 384c-44.2 0-80-35.8-80-80l0-16 160 0 0 16c0 44.2-35.8 80-80 80z\"\/><\/svg><\/div><p><div class=\"rrze-elements alert clearfix clear\" style=\"\" ><\/span><\/p>\n<p><span style=\"font-family: helvetica, arial, sans-serif\"><a href=\"https:\/\/miracum.cms.rrze.uni-erlangen.de\/files\/2022\/03\/miracum_uc1_brochure.pdf\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-5724 aligncenter\" src=\"https:\/\/miracum.cms.rrze.uni-erlangen.de\/files\/2022\/03\/miracum_uc1_brochure_cover-211x300.jpg\" alt=\"\" width=\"211\" height=\"300\" srcset=\"https:\/\/www.miracum.org\/files\/2022\/03\/miracum_uc1_brochure_cover-211x300.jpg 211w, https:\/\/www.miracum.org\/files\/2022\/03\/miracum_uc1_brochure_cover-722x1024.jpg 722w, https:\/\/www.miracum.org\/files\/2022\/03\/miracum_uc1_brochure_cover-768x1089.jpg 768w, https:\/\/www.miracum.org\/files\/2022\/03\/miracum_uc1_brochure_cover-1083x1536.jpg 1083w, https:\/\/www.miracum.org\/files\/2022\/03\/miracum_uc1_brochure_cover-1444x2048.jpg 1444w, https:\/\/www.miracum.org\/files\/2022\/03\/miracum_uc1_brochure_cover-406x576.jpg 406w, https:\/\/www.miracum.org\/files\/2022\/03\/miracum_uc1_brochure_cover-486x690.jpg 486w, https:\/\/www.miracum.org\/files\/2022\/03\/miracum_uc1_brochure_cover.jpg 1749w\" sizes=\"auto, (max-width: 211px) 100vw, 211px\" \/><\/a><\/span><\/p>\n<p style=\"text-align: center\"><span style=\"font-family: helvetica, arial, sans-serif\">Use Case 1 Booklet<\/span><\/p>\n<p><span style=\"font-family: helvetica, arial, sans-serif\"><\/div>\n<\/p><\/div><\/p>\n<\/p><\/aside><\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-family: helvetica, arial, sans-serif\">Clinical studies often fail due to the insufficient number of suitable study participants. In the use case \u201cAlerting in Care \u2013 IT Support for Patient Recruitment\u201d the consortium MIRACUM integrates recruitment platforms into the Hospital Information System environments at each of its participating university hospitals. This will support recruitment processes with innovative IT solutions applying existing routine data.<\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-family: helvetica, arial, sans-serif\">New therapeutic options, whether drugs, treatment methods or other medical products, are subject to complex testing procedures, including the conduct of studies. For pursuing such studies those responsible for the studies often face one major challenge: identifying and recruiting sufficient participants in a timely manner. In a university hospital\u00b4s busy daily routine with many studies running at the same time, today efficient tools are missing, which would easily identify patients who are eligible for the respective studies. Therefore, Use Case 1 of the MIRACUM consortium is developing a digital recruitment platform that is designed to automatically check who is suitable for a study based on existing patient data.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: justify\"><span style=\"font-family: georgia, palatino, serif\"><div class=\"rrze-elements accordion style_default\" id=\"accordion-0\">\n<div class=\"accordion-group fau\">\n<h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\"  href=\"#collapse_0\" aria-expanded=\"false\" aria-controls=\"collapse_0\" id=\"collapse_button_0\"> Read more <\/button><\/h2>\n<div id=\"collapse_0\" class=\"accordion-body\" aria-labelledby=\"collapse_button_0\">\n<div class=\"accordion-inner clearfix\"><\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-family: helvetica, arial, sans-serif\">As a first step, all MIRACUM sites have harmonized their study description criteria and consented on a joined information model for a FHIR-based study description. Based on this all MIRACUM sites have established local study registries and initiated processes to continuously enter and maintain study descriptions of all clinical trials pursued at their sites. As early as the second half of 2019, the local study registries at the MIRACUM sites began to enter study data in a standardized manner. The study information from these local implementations is also recorded in a MIRACUM-wide central study registry, in which information on the individual studies can be searched across all sites. The central registry uses a FHIR-based interface to receive study information from all local registries. A web interface allows keyword searches and filtering by participating centers and study category. The website of the central registry is available at \u00a0<a class=\"external-link\" href=\"http:\/\/studien.miracum.org\" rel=\"nofollow\">studien.miracum.org<\/a>. Up-to-date information is guaranteed by automated exports from the local registries.<\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-family: helvetica, arial, sans-serif\">The FHIR standard is also used for the implementation of IT-supported patient recruitment: An FHIR server serves as a central integration and communication platform. A search module is based on the central databases of the data integration centers at the MIRACUM sites to determine which of the patients currently enrolled are potential subjects for a study. These patients are placed on a screening list, which doctors can view as a clinic-internal web application. At the same time, a notification tool informs them about current recruitment proposals by e-mail. The physician then has the opportunity to check the respective patient file and recommend the patient to participate in the respective study. The procedure is now to be examined in an evaluation study in order to derive further optimization options.<\/span><\/p>\n<p><span style=\"font-family: georgia, palatino, serif\"><\/div>\n<\/div>\n<\/div>\n<div class=\"accordion-group fau\">\n<h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\"  href=\"#collapse_1\" aria-expanded=\"false\" aria-controls=\"collapse_1\" id=\"collapse_button_1\"> Publications <\/button><\/h2>\n<div id=\"collapse_1\" class=\"accordion-body\" aria-labelledby=\"collapse_button_1\">\n<div class=\"accordion-inner clearfix\"><\/span><\/p>\n<div>\n<p><span style=\"font-family: helvetica, arial, sans-serif\">Gulden C, Macho P, Reinecke I, Strantz C, Prokosch HU, Blasini R. <\/span><span style=\"font-family: helvetica, arial, sans-serif\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0010482524004955?via%3Dihub\">recruIT: A cloud-native clinical trial recruitment support system based on Health Level 7 Fast Healthcare Interoperability Resources (HL7 FHIR) and the Observational Medical Outcomes Partnership Common Data Model (OMOP CDM)<\/a>. <\/span><span style=\"font-family: helvetica, arial, sans-serif\">Computers in Biology and Medicine. 2024<em>;<\/em> in Press. DOI: https:\/\/doi.org\/10.1016\/j.compbiomed.2024.108411.<\/span><\/p>\n<p><span style=\"font-family: helvetica, arial, sans-serif\">Boeker M, Z\u00f6ller D, Blasini R, Macho P, Helfer S, Behrens M, Prokosch HU, Gulden C<em>. <\/em><\/span><span style=\"font-family: helvetica, arial, sans-serif\"><a href=\"https:\/\/trialsjournal.biomedcentral.com\/articles\/10.1186\/s13063-024-07918-z\">Effectiveness of IT-supported patient recruitment: study protocol for an interrupted time series study at ten German university hospitals. <\/a><\/span><span style=\"font-family: helvetica, arial, sans-serif\">Trials. 2024; 25:125. DOI: 10.1186\/s13063-024-07918-z.<\/span><\/p>\n<p><span style=\"font-family: helvetica, arial, sans-serif\">Blasini R, Strantz C, Gulden C, Helfer S, Lidke J, Prokosch HU, Sohrabi K, Schneider H. <\/span><span style=\"font-family: helvetica, arial, sans-serif\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38294862\/\">Evaluation of Eligibility Criteria Relevance for the Purpose of IT-Supported Trial Recruitment: Descriptive Quantitative Analysis<\/a>. <\/span><span style=\"font-family: helvetica, arial, sans-serif\">JMIR Form Res. 2024; 8:e49347. DOI: 10.2196\/49347.<\/span><\/p>\n<\/div>\n<div class=\"content-wrapper\"><span class=\"info__authors\" style=\"font-family: helvetica, arial, sans-serif\">Henke E, Peng Y, Reinecke I, Zoch M, Sedlmayr M, Bathelt F.<a href=\"https:\/\/medinform.jmir.org\/2023\/1\/e47310\"> An Extract-Transform-Load Process Design for the Incremental Loading of German Real-World Data Based on FHIR and OMOP CDM: Algorithm Development and Validation<\/a>. JMIR Med Inform 2023; 11:e47310. DOI: 10.2196\/47310.<\/span><\/div>\n<p><span style=\"font-family: helvetica, arial, sans-serif\">Peng Y, Henke E, Reinecke I, Zoch M, Sedlmayr M, Bathelt F. <a class=\"external-link\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1386505622002398?via%3Dihub\" rel=\"nofollow\">An ETL-process design for data harmonization to participate in international research with German real-world data based on FHIR and OMOP CDM.\u00a0<\/a>Int J Med Inform 2023; 169:104925. DOI: 10.1016\/j.ijmedinf.2022.104925.<\/span><\/p>\n<p><span style=\"font-family: helvetica, arial, sans-serif\">Gulden C, Blasini R, Nassirian A, Stein A, Altun F, Kirchner M, Prokosch H, Boeker M. <a class=\"external-link\" href=\"https:\/\/medinform.jmir.org\/2021\/1\/e20470\" rel=\"nofollow\">Prototypical Clinical Trial Registry Based on Fast Healthcare Interoperability Resources (FHIR): Design and Implementation Study.<\/a> JMIR Med Inform 2021; 9:e20470. DOI: 10.2196\/20470.<\/span><\/p>\n<p><span style=\"font-family: helvetica, arial, sans-serif\">Reinecke I, Gulden C, K\u00fcmmel M, Nassirian A, Blasini R, Sedlmayr M. <a class=\"external-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32570366\/\" rel=\"nofollow\">Design for a Modular Clinical Trial Recruitment Support System Based on FHIR and OMOP<\/a>.\u00a0S<span class=\"period\">tud Health Technol Inform. 2020<\/span><span class=\"cit\">;270:158-162. <\/span><span class=\"citation-doi\">DOI: 10.3233\/SHTI200142. <\/span><span class=\"identifier pubmed\"><span class=\"id-label\">PMID:\u00a0<\/span>32570366.<\/span><\/span><\/p>\n<p><span style=\"font-family: helvetica, arial, sans-serif\">Becker L, Ganslandt T, Prokosch HU, Newe A. <a class=\"external-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32442156\/\" rel=\"nofollow\">Applied practice and possible leverage points for information technology support for the screening for clinical trials: A qualitative study<\/a>.\u00a0JMIR Med Inform. 2020;8:e15749. <span class=\"identifier doi\"><span class=\"id-label\">DOI: <\/span>10.2196\/15749.\u00a0PMID:\u00a032442156.<\/span><\/span><\/p>\n<p><span style=\"font-family: helvetica, arial, sans-serif\"><span class=\"content\"><span class=\"text surname\">Gulden C<\/span>, <\/span><span class=\"content\"><span class=\"text surname\">Kirchner M<\/span>, <\/span><span class=\"content\"><span class=\"text surname\">Sch\u00fcttler C<\/span>, <\/span><span class=\"content\"><span class=\"text surname\">Hinderer M<\/span>, <\/span><span class=\"content\"><span class=\"text surname\">Kampf M<\/span>, <\/span><span class=\"content\"><span class=\"text surname\">Prokosch HUP<\/span>, <\/span><span class=\"content\"><span class=\"text surname\">Toddenroth D. <span class=\"title-text\"><a class=\"external-link\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S138650561830933X\" rel=\"nofollow\">Extractive summarization of clinical trial descriptions<\/a>. Int J Med Inform. 2019;129:114-121. DOI: 10.1016\/j.ijmedinf.2019.05.019. <span class=\"identifier pubmed\"><span class=\"id-label\">PMID: <\/span> 31445245.<\/span><br \/>\n<\/span><\/span><\/span><\/span><\/p>\n<p><span style=\"font-family: helvetica, arial, sans-serif\"><span class=\"content\"><span class=\"text surname\">Gulden C, Landerer I, Nassirian A, Altun FB, Andrae J. <a class=\"external-link\" href=\"http:\/\/ebooks.iospress.nl\/publication\/51389\" rel=\"nofollow\">Extraction and Prevalence of Structured Data Elements in Free-Text Clinical Trial Eligibility Criteria<\/a>. Stud Health Technol Inform. 2019;258:226-230. DOI:\u00a0<\/span><\/span><span class=\"identifier doi\">10.2196\/15749.\u00a0<\/span><span class=\"content\"><span class=\"text surname\">PMID: 30942751.<br \/>\n<\/span><\/span><\/span><\/p>\n<p><span class=\"content\" style=\"font-family: helvetica, arial, sans-serif\"><span class=\"text surname\">Hasselblatt H, Andrae J, Tassoni A, Fitzer K, Bahls T, Prokosch HU, Boeker M. <a class=\"external-link\" href=\"http:\/\/ebooks.iospress.nl\/publication\/51387\" rel=\"nofollow\">Establishing an Interoperable Clinical Trial Information System Within MIRACUM<\/a>.\u00a0Stud Health Technol Inform. 2019;258:216-220. Doi:\u00a010.3233\/978-1-61499-959-1-216. PMID:\u00a030942749.<br \/>\n<\/span><\/span><\/p>\n<p><span style=\"font-family: helvetica, arial, sans-serif\"><span class=\"content\"><span class=\"text surname\">Sommer M, Kirchner M, Gulden C, Egloffstein S, Lux MP, Beckmann MW, Mackensen A, Prokosch HU. <a class=\"external-link\" href=\"http:\/\/ebooks.iospress.nl\/publication\/51376\" rel=\"nofollow\">Design and Implementation of a Single Source Multipurpose Hospital-Wide Clinical Trial Registry<\/a>. Stud Health Technol Inform. 2019;258:164-168. DOI: 10.3233\/978-1-61499-959-1-164. PMID:\u00a0<\/span><\/span><span class=\"identifier pubmed\">30942738.<\/span><\/span><\/p>\n<p><span style=\"font-family: helvetica, arial, sans-serif\">Gulden C, Mate S, Prokosch HU, Kraus S. <a class=\"external-link\" href=\"http:\/\/ebooks.iospress.nl\/publication\/50011\" rel=\"nofollow\">Investigating the Capabilities of FHIR Search for Clinical Trial Phenotyping<\/a>.\u00a0<span class=\"content\"><span class=\"text surname\">Stud Health Technol Inform. 2018;253:3-7. DOI: 10.3233\/978-1-61499-896-9-3. 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background-color:#fff; color:#fff\" target=\"_blank\"><span class=\"shariff-icon\" style=\"\"><svg width=\"32px\" height=\"20px\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 11 32\"><path fill=\"#999\" d=\"M11.4 24v2.3q0 0.5-0.3 0.8t-0.8 0.4h-9.1q-0.5 0-0.8-0.4t-0.4-0.8v-2.3q0-0.5 0.4-0.8t0.8-0.4h1.1v-6.8h-1.1q-0.5 0-0.8-0.4t-0.4-0.8v-2.3q0-0.5 0.4-0.8t0.8-0.4h6.8q0.5 0 0.8 0.4t0.4 0.8v10.3h1.1q0.5 0 0.8 0.4t0.3 0.8zM9.2 3.4v3.4q0 0.5-0.4 0.8t-0.8 0.4h-4.6q-0.4 0-0.8-0.4t-0.4-0.8v-3.4q0-0.4 0.4-0.8t0.8-0.4h4.6q0.5 0 0.8 0.4t0.4 0.8z\"\/><\/svg><\/span><\/a><\/li><\/ul><\/div>","protected":false},"excerpt":{"rendered":"<p>IT Support for Patient Recruitment Clinical studies often fail due to the insufficient number of suitable study participants. In the use case \u201cAlerting in Care \u2013 IT Support for Patient&hellip;<!--&hellip;--> <a class=\"more-link fa fa-angle-double-right\" href=\"https:\/\/www.miracum.org\/en\/forschung\/archiv\/use-cases\/use-case-1-alerting-care\/\" title=\"Read more about &quot;Use Case 1 - Alerting in Care&quot;\"><\/a><\/p>\n","protected":false},"author":3748,"featured_media":6210,"parent":6773,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_rrze_cache":"enabled","_rrze_multilang_single_locale":"en_US","_rrze_multilang_single_source":"https:\/\/miracum.cms.rrze.uni-erlangen.de\/?page_id=6196","footnotes":""},"page_category":[],"page_tag":[],"workflow_usergroup":[],"class_list":["post-6801","page","type-page","status-publish","has-post-thumbnail","hentry","en-US"],"_links":{"self":[{"href":"https:\/\/www.miracum.org\/wp-json\/wp\/v2\/pages\/6801","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.miracum.org\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.miracum.org\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.miracum.org\/wp-json\/wp\/v2\/users\/3748"}],"replies":[{"embeddable":true,"href":"https:\/\/www.miracum.org\/wp-json\/wp\/v2\/comments?post=6801"}],"version-history":[{"count":6,"href":"https:\/\/www.miracum.org\/wp-json\/wp\/v2\/pages\/6801\/revisions"}],"predecessor-version":[{"id":10203,"href":"https:\/\/www.miracum.org\/wp-json\/wp\/v2\/pages\/6801\/revisions\/10203"}],"up":[{"embeddable":true,"href":"https:\/\/www.miracum.org\/wp-json\/wp\/v2\/pages\/6773"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.miracum.org\/wp-json\/wp\/v2\/media\/6210"}],"wp:attachment":[{"href":"https:\/\/www.miracum.org\/wp-json\/wp\/v2\/media?parent=6801"}],"wp:term":[{"taxonomy":"page_category","embeddable":true,"href":"https:\/\/www.miracum.org\/wp-json\/wp\/v2\/page_category?post=6801"},{"taxonomy":"page_tag","embeddable":true,"href":"https:\/\/www.miracum.org\/wp-json\/wp\/v2\/page_tag?post=6801"},{"taxonomy":"workflow_usergroup","embeddable":true,"href":"https:\/\/www.miracum.org\/wp-json\/wp\/v2\/workflow_usergroup?post=6801"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}