Interactive generation and simulation of prognostic, personalized digital patient models
About the project
Neurostimulation strategies such as deep brain stimulation and spinal cord stimulation have demonstrated to be clinically effective treatments for various neurological disorders, e.g. Parkinson’s disease or neuropathic pain. Neurostimulation offers a promising and more targeted alternative to pharmacological approaches potentially without systemic side effects. As the mechanisms of action of neurostimulation strategies remain to be determined, the identification of optimal or even appropriate stimulation parameters remains challenging. Moreover, the most effective stimulation parameter may vary from subject to subject, and stimulation parameters that have been configured for one application may not be effective for another. It remains to be determined if the same stimulation parameters can be used for the treatment of multiple dysfunctions (i.e. locomotor recovery versus restoration of bladder function) or if different stimulation parameters will be required. Additionally, there remains a gap in translating preclinical studies to clinical applications. We believe that the goal of determining successful parameters for neurostimulation strongly depends on novel modeling tools that can determine the underlying mechanisms of action and identify optimal stimulation strategies on a per subject basis.
The research group ProModell aims to initiate a breakthrough for in-silico development of novel neurostimulation strategies and precise planning of neurotherapies. We develop computational tools for the rapid generation of anatomically, physically, and neurofunctionally accurate digital twins. Digital neuro-twins will enable investigators and clinicians to develop and deploy effective, safe, and robust neurostimulation strategies.
Lead of the Junior Research Group
Dr. Andreas Rowald
Lead of the Junior Research Group ProModell
Chair of Digital Health | Friedrich-Alexander-Universität Erlangen-Nürnberg
- Rowald et al. – Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis. Nat Med 2022; 28:260–271. DOI: 10.1038/s41591-021-01663-5.
- i24 News English – New implant gives paralyzed man ability to walk
- WGN News – Spinal Implant Helps Paralyzed Man Walk Again
- MIRACUM Symposium 2021 – Erzeugung und Simulation prognostischer Patientenmodellen
- Neurology Podcast – Neuromodulation Restores Function in Spinal Cord Injury
News / Articles